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Objective: In this study our main aim is to evaluate impact ofSerum Total IgE and Disease Severity in Patients with AllergicAsthma.Method: This cross-sectional study was conducted at NIDCH,Mohakhali, Dhaka from one year (July 2012 - June2013).Among 150 asthma patients, 50 mild asthma patients, 50moderate and 50 severe asthma were selected in this study.Result: In our study among 150 patients, patients with midasthma belong to 15-19 years age group, where as patientswith moderate asthma and severe asthma belong to 25-29years and 35-39 years age group.21% patients with mildasthma unusually visit for regular checkup to doctor whereas48% patients with moderate asthma unusually visit regularly todoctor.47% patients with severe asthma level had >400 IU/mLserum level where as 19% patients with moderate asthma had>400 IU/mL serum level.Conclusion: From our study we can conclude that, serum totalIgE levels in adult patients with persistent allergic asthma fromBangladesh were high (two-thirds with levels >150 IU/mL) andvaried significantly. Further study is highly appreciated forbetter outcome.
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Objective To provide clues for the diagnosis standard, laboratory examination and pathological mechanism of asthma and chronic obstructive pulmonary disease overlap syndrome(ACOS) by detecting the levels of serum total IgE, fractional exhaled nitric oxide (FeNO) and peripheral blood oxyphil cells in asthma, chronic obstructive pulmonary disease (C0PO) and ACOS. Methods A prospective randomized trial based on hospital was conducted. According to the diagnostic criteria and inclusion criteria, 40 asthma patients(asthma group), 25 cases of patients with COPD(COPD group)and 37 cases of ACOS patients(ACOS group)were collected continuously, and 40 healthy persons(healthy control group) were as the research object. General data and biochemical indexes were tested in each group. The levels of serum total IgE, FeNO and peripheral blood oxyphil cells in each group were observed and compared.The correlation between serum total IgE and other biochemical parameters were analyzed by Pearson correlation analysis. Results The level of total serum IgE in asthma group was significantly higher than that in other groups(P<0.05),and the level of total serum IgE in ACOS group was the second(P<0.05).The level of total serum IgE in healthy control group and COPD group had no significant difference(P>0.05).The level of FeNO in four groups had significant difference(P<0.05), and the level of FeNO in ACOS group and asthma group had significant difference compared with that of COPD group (P < 0.05). The level of peripheral blood oxyphil cells in asthma group, ACOS group, COPD group was significantly higher than that in healthy control group (P < 0.05), and the change of ACOS group was the best obviously.Conclusions Serum total IgE, FeNO and peripheral blood oxyphil cells are specific detection index in ACOS.Combined detection can help to identify ACOS, asthma and COPD, also reveal the presence of airway inflammation in the pathogenesis of ACOS, and can provide the basis for clinical diagnosis, treatment and prevention.
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Objective To observe the therapeutic effect of Guizhi Decoction plus Yupingfeng Powder for chronic urticaria and its effect on serum total IgE level.Methods One hundred and twenty patients were randomly divided into treatment group,control group 1 and control group 2,40 cases in each group.The treatment group was treated with Guizhi Decoction,Yupingfeng Powder and Loratadine Tablets orally,the control group 1 was given intramuscular injection of Bacillus Calmette-Guerin polysaccharide nucleic acid and oral use of Loratadine Tablets,and the control group 2 was only given oral use of Loratadine Tablets.The course of treatment covered 5 weeks.The levels of serum total IgE in the three groups were determined before and after treatment,and the therapeutic effect was evaluated after treatment.Results (1) The total effective rate was 85.0％ in the treatment group,80.0％ in the control group 1,and 55.0％ in the control group 2.The effect of control group 1 and the treatment group was superior to that of the control group 2 (P＜ 0.05),but the difference was insignificant between the treatment group and control group 1 (P＞ 0.05).(2)Before treatment,the serum total IgE level of the three groups was higher than that of the normal control group (P ＜ 0.05).After treatment,the serum total IgE level of the three groups was obviously decreased (P ＜ 0.05 compared with that before treatment);the inter-group comparison results showed that the effect of the treatment group and control group 1 on decreasing the serum total IgE level was superior to that of the control group 2(P ＜ 0.05),while the effect of the treatment group was similar to that of the control group 1 (P ＞0.05).(3) During the treatment,blood routine examination indexes and hepato-renal function of the three groups showed no abnormal changes,neither adverse reaction was shown.Conclusion Guizhi Decoction plus Yupingfeng Powder exerts certain therapeutic effect for the treatment of chronic urticaria,and can decrease the serum total IgE level,thus to stabilize the curative effect and reduce the recurrence.
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PURPOSE: Serum total and specific IgE levels have been widely used to diagnose allergic disease. However, it has recently been suggested that serum total IgE does not properly reflect specific IgE. Therefore, we evaluated the clinical significance of serum total IgE in pediatric allergic disease. METHODS: This study included 633 patients who visited Kyungpook National University Children's Hospital between March 2013 and April 2015. We used immunoCAP, an inhalant multiple allergen simultaneous test (MAST), and food MAST to measure specific IgE. We used a skin prick test in some patients and measured serum total IgE, eosinophil count, and serum eosinophil cationic protein in all patients. RESULTS: There was a positive correlation between serum total IgE and antigen level in the inhalant immunoCAP test. Specifically, the sum of immunoCAP levels was highly correlated with serum total IgE (r=0.631, P<0.001). Moreover, there was a positive correlation between serum total IgE and the sum of food immunoCAP levels (r=0.323, P<0.001). Among the food immunoCAP antigens, milk was highly correlated with serum total IgE (r=0.558, P<0.001). There was a positive correlation between serum total IgE and the sum of class levels of inhalant/food MAST tests (r=0.709, P<0.001 and r=0.686, P<0.001, respectively). There was also a positive correlation between serum total IgE and the number of positive skin prick tests (r=0.445, P<0.001). CONCLUSION: Serum total IgE may reflect the sum of serum specific IgE levels in pediatric allergic disease.
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Humans , Eosinophil Cationic Protein , Eosinophils , Immunoglobulin E , Milk , SkinABSTRACT
This study was aimed to investigate allergic reactions of traditional Chinese medicine (TCM) injections, and to determine contents of serum IgE in sensitized animals. The correlation between preceding contents in serum and allergic reactions may be found, in order to offer experimental evidences for advancing the accuracy of anticipa-tion by allergic reactions. Passive cutaneous anaphylaxis (PCA) tests and anaphylactoid reactions were used in a vari-ety of TCM injections. ELISA method was used to determine the content of total serum IgE in sensitized animals. The PCA results of SHL, QKL, YXC, XST, GGS and CHN were negative. The PCA result of CWJ was positive. There was no significant difference for total serum IgE level between the experimental group and the normal saline group in the group of SHL, QKL, YXC, XST, GGS, CHN and CWJ. All TCM injections caused anaphylactoid symp-toms in guinea pigs. It was concluded that all TCM injections can cause allergic reactions in guinea pig. And the al-lergic reactions of TCM injections were not correlated with serum total IgE.
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BACKGROUND: Staphylococcus aureus (SA) has peculiar abilities to colonize the skin in atopic dermatitis (AD) patients. OBJECTIVE: We sought to determine the colonization rates of SA in acute and chronic skin lesions of AD patients, to find any difference in colonization rates according to age and to find the influences of total immunoglobulin E (IgE) and eosinophil counts to the colonization of SA. METHODS: We evaluated the total IgE level and eosinophil counts, and cultured SA from the skin lesions of 687 AD patients (131 acute and 556 chronic skin lesions) and 247 control urticaria patients (July 2009 to November 2010; Samsung Medical Center Dermatology Clinic, Seoul, Korea). RESULTS: The SA colonization rates were 74%, 38% and 3% in acute, chronic skin lesions and control skin, respectively, and they were increased with age in AD patients. The colonization rate in chronic skin lesions was higher in the high IgE/eosinophilia groups as compared to the normal IgE/eosinophil groups. CONCLUSION: The SA colonization rate was higher in AD patients and especially in acute lesions, and had a tendency to increase with age. As the colonization rates were only higher in the high IgE/eosinophilia groups of chronic skin lesions, we suggested that SA may invade the skin through barrier defects in acute skin lesions, but the colonization in chronic lesions may be orchestrated through many different factors.
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Humans , Colon , Dermatitis, Atopic , Dermatology , Eosinophils , Immunoglobulin E , Immunoglobulins , Skin , Staphylococcus aureus , Staphylococcus , UrticariaABSTRACT
PURPOSE: Elevated IgE, and blood eosinophil count are considered the hallmarks of allergic diseases, while the levels of those parameters are shared with normal population. This study is aimed to investigate the relationship between those factor and clinical value according to specific allergic diseases. METHODS: We reviewed medical records of 946 patients with allergic diseases who had taken the allergy tests from 2001 to 2010. The effects of age, sex, specific diagnoses of diseases, such as atopic dermatitis (AD), allergic rhinitis (AR), bronchial asthma (BA), urticarial on allergy tests were assessed. RESULTS: In contrast to those of total eosinophil counts, there was the trend of increasing IgE value with the age in children with allergic diseases. The titer of total IgE and eosinophil count were higher than those of control group of patients with acute urticaria. There was the positive relation between total IgE and eosinophil count in patients with allergic diseases. The positive predictive value and negative predictive value of total IgE for specific IgE were higher than those of total eoshinophil count. CONCLUSION: There were the positive relation of total IgE and total eosinophil count in allergic diseases and the higher value of those compared with the control in this study. These values over a certain level have a positive predictive value of serum specific IgE and help us to determine whether we should test the serum specific IgE in patients with allergic diseases.
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Child , Humans , Asthma , Dermatitis, Atopic , Eosinophils , Hypersensitivity , Immunoglobulin E , Medical Records , Rhinitis , Rhinitis, Allergic, Perennial , UrticariaABSTRACT
BACKGROUND: OME is a multifactorial disease. It has long been recognized that eustachian tube dysfunction or obstruction predisposes to OME. Some researchers suggested that histamine released from adenoid mast cell, is another possible factor for eustachian tube dysfunction. But, it is controvertial that the increased population of adenoid mast cell in patients with OME. MATERIALS AND METHODS: 38 of children who were done tonsillectomy and adenoidectomy with or without insertion of ventilation tube, were the subjects of this study. The mast cells were identified and counted in the tonsillectomy specimens and adenoidectomy specimens. Total IgE was measured in the serum of each patient with PRIST. RESULTS: The population of adenoid mast cell was increased in the OME group than control group. But, the population of tonsillar mast cell, and serum total IgE were not associated with OME. CONCLUSIONS: Increased population of adenoid mast cell was related to the pathogenesis of OME.
Subject(s)
Child , Humans , Adenoidectomy , Adenoids , Eustachian Tube , Histamine , Immunoglobulin E , Mast Cells , Otitis Media with Effusion , Otitis Media , Otitis , Tonsillectomy , VentilationABSTRACT
PURPUSE: Serum IgE have been shown to be related to allergic disease and used for an initial diagnosis of allergic diseases. House dust mite such as Dermatophagoides pteronyssinus(Dp) and D. farinae(Df) is very important for inhalant allergens, which may be a cause and/or triggering factor of atopic diseases. On the other hand, eosinophil cationic protein (ECP) causes epithelial damages of the airway, and bronchial hyperresponsiveness has been used as a useful indication of allergic inflammation. To date, there are few studies on the longitudinal patterns of total and inhalant allergen-specific IgE, and ECP in normal children in Korea. The present study was performed to determine the reference levels of serum total and Dp- and Df-specific IgE and ECP in healthy children under 7 years of age by the groups of different age and gender. METHODS: Total, and Dp- and Df-specific IgE and ECP concentrations were measured by fluoroimmunoassay(UniCAP, Pharmacia-UpJohn, Sweden) in serum from 449 healthy children under 7 years of age by using a population-based cohort followed from 1996 through 1997. All subjects were enrolled from eight large health organizations in geographically defined area such as Seoul and four local cities. RESULTS: Serum total IgE concentration showed steady increase with age from birth to 4 years, and a plateau. In contrast, Dp- and Df-IgE levels showed apparently continuous increments after 4 years of age. ECP showed variable increase until 4 years of age and slow decrease afterwards. There were no statistically significant differences in those results by gender and/or the living area, but much higher increments of Dp- and Df-IgE of boys from 3 years of age through 6 years were found. CONCLUSION: We found feasible results of total, Dp- and Df-specific IgE, and ECP in serum from healthy children under seven years of age, which may be useful for a reference.